THE AIM OF THE CLINIMARK NETWORK IS TO ESTABLISH A ‘BEST BIOMARKER PRACTICE’ COMMUNITY TO SIGNIFICANTLY INCREASE THE NUMBER OF BIOMARKERS WITH REPRODUCIBLY DEMONSTRATED FEASIBILITY.
Thousands of circulating proteins have been shown to be hallmarks of emerging disease, response to treatment, or a patients’ prognosis. The identification of these small molecule biomarkers holds a great promise for significant improvement of personalized medicine based on simple blood tests.
For instance, diagnosis and prognosis with biomarkers (e.g. carcinoembryonic antigen (CEA)) has significantly improved patient survival and decreased healthcare costs in colorectal cancer patients. Unfortunately, despite significant investments to increase the number of biomarker studies, only ~150 out of thousands of identified biomarkers have currently been implemented in clinical practice.
ROBoCoP: a Respiratory disease Occupational Biomonitoring Collaborative Project
Chronic obstructive pulmonary disease (COPD) is a major public health problem with a prevalence in Switzerland reaching 15.9% in men. Exposure to particulate matter (PM) is a known COPD risk factor via oxidative stress pathway. Reactive oxygen species (ROS) and their metabolites could be predictive to COPD onset and be used as diagnostic biomarkers.
ROBoCop project, in the framework of CliniMark EU-COST Action, aims to select and validate a panel of oxidative stress biomarkers analyzed in non-invasive biological samples.
(Posted on 11 January 2018)
Waters MS Technology Days 2017: Evaluation of biomarkers predictive for Alzheimer's disease
During the Waters MS Technology Days 2017 in Basel (6/27) and Lausanne (6/27) research results were presented from a BDC study carried out in the group of Dr. Theo Luider at the Erasmus MC (Rotterdam) about development and application of an LC-MS assay to evaluate Pregnancy Zone Protein as potential biomarker for the prediction of Alzheimer's disease. Information about the meeting here.(Posted on 24 August 2017)
EATRIS, the European Infrastructure for Translational Medicine in which the BDC laboratories of profs Bischoff, Luider and van Gool are members, will hold its annual Translational Conference in Prague, September 24-26. Conference information here.
(Posted 17 May 2017)
Bridging the translational innovation gap through good biomarker practice
In collaboration with the European technology infrastructures EATRIS, BBMRI and ELIXIR, prof van Gool and other scientists from the Biomarker Development Center published a comment in Nature Reviews Drug Discovery to join efforts in defining the Good Biomarker Principle guidelines that will support successful biomarker discovery and development activities. These guidelines will be defined in the COST action CliniMARK, initiated and coordinated by dr Luider of the BDC. See comment here.
(Posted 10 May 2017)
(Posted 20 March 2017)