Clinical Proteomics: Closing the Gap from Discovery to Implementation.
DATE - 2019 Jul 09
Clinical proteomics, the application of proteome analysis to serve a clinical purpose, represents a major ﬁeld in the area of proteome research. Over 1000 manuscripts on this topic are published each year, with numbers continuously increasing. However, the anticipated outcome, the transformation of the reported ﬁndings into improvements in patient management, is not immediately evident.
In this article, the value and validity of selected clinical proteomics ﬁndings are investigated, and it is assessed how far implementation has progressed. A main conclusion from this assessment is that to achieve implementation, well-powered clinical studies are required in the appropriate population, addressing a speciﬁc clinical need and with a clear context-of-use. Eﬀorts toward implementation, to be feasible, must be supported by the key players in science: publishers and funders.
The authors propose a change on objectives, from additional discovery studies toward studies aiming at validation of the plethora of potential biomarkers that have been described, to demonstrate practical value of clinical proteomics. All elements required, potential biomarkers, technologies, and bio-banked samples are available (based on today’s literature), hence a change in focus from discovery toward validation and application is not only urgently necessary, but also possible based on resources available today.